Anti-Localization in Oxides: Effective Spin-3/2 Model

Weak anti-localization offers an experimental tool to address spin--orbit coupling of two-dimensional oxide surfaces and interfaces via magneto-transport. To overcome the shortcomings of the formulation for single-band spin-1/2 electrons, we consider an effective three-band model that allows a decomposition into a pseudo-spin representation 1/2+3/2. Whereas the well-established spin-1/2 transport signature results from the singlet and triplet sectors in the Cooperon equation, a new structure originates from the quintet and septet sectors generated by the spin 3/2x3/2 representation

Momentum-Space Spin Texture in a Topological Superconductor

A conventional superconductor with spin-orbit coupling turns into a topological superconductor beyond a critical strength of the Zeeman energy. The spin-expectation values $\mathbf{S}(\mathbf{k})$ in momentum space trace this transition via a characteristic change in the topological character of the spin texture within the Brillouin zone. At the transition the skyrmion counting number switches from 0 to 1/2 identifying the topological superconductor via its meron-like spin texture. The change in the skyrmion counting number is crucially controlled by singular points of the map $\mathbf{S}(\mathbf{k})/|\mathbf{S}(\mathbf{k})|$ from the Brillouin zone, i.e. a torus, to the unit sphere. The complexity of this spin-map is discussed at zero temperature as well as for the extension to finite temperatures.Comment: 16 pages, 9 figure

The Dark Matter equation of state through cosmic history

Cold Dark Matter (CDM) is a crucial constituent of the current concordance cosmological model. Having a vanishing equation of state (EoS), its energy density scales with the inverse cosmic volume and is thus uniquely described by a single number, its present abundance. We test the inverse cosmic volume law for Dark Matter (DM) by allowing its EoS to vary independently in eight redshift bins in the range $z=10^5$ and $z=0$. We use the latest measurements of the Cosmic Microwave Background radiation from the Planck satellite and supplement them with Baryon Acoustic Oscillation (BAO) data from the 6dF and SDSS-III BOSS surveys, and with the Hubble Space Telescope (HST) key project data. We find no evidence for nonzero EoS in any of the eight redshift bins. With Planck data alone, the DM abundance is most strongly constrained around matter-radiation equality $\omega^{\rm eq}_g = 0.1193^{+0.0036}_{-0.0035}$ (95% c.l.), whereas its present day value is more weakly constrained $\omega^{(0)}_g = 0.16^{+0.12}_{-0.10}$ (95% c.l.). Adding BAO or HST data does not significantly change the $\omega^{\rm eq}_g$ constraint, while $\omega^{(0)}_g$ tightens to $0.160^{+0.069}_{-0.065}$ (95% c.l.) and $0.124^{+0.081}_{-0.067}$ (95% c.l.) respectively. Our results constrain for the first time the level of "coldness" required of the DM across various cosmological epochs and show that the DM abundance is strictly positive at all times.Comment: 6 pages, 4 figures, changed color scheme for figure

How clicks on a job platform can reveal gender, ethnic, and racial bias

Education and skills should be the key determinants of whether a candidate gets a job or not, but in reality, gender, origin or race/ethnicity end up influencing hiring decisions. By leveraging big data from recruitment platforms and machine learning to study hiring discrimination, Dominik Hangartner, Daniel Kopp, and Michael Siegenthaler show that discrimination against immigrants depends, among other things, on their origin and time of day; and that both men and women face discrimination

DDoS Never Dies? An IXP Perspective on DDoS Amplification Attacks

DDoS attacks remain a major security threat to the continuous operation of Internet edge infrastructures, web services, and cloud platforms. While a large body of research focuses on DDoS detection and protection, to date we ultimately failed to eradicate DDoS altogether. Yet, the landscape of DDoS attack mechanisms is even evolving, demanding an updated perspective on DDoS attacks in the wild. In this paper, we identify up to 2608 DDoS amplification attacks at a single day by analyzing multiple Tbps of traffic flows at a major IXP with a rich ecosystem of different networks. We observe the prevalence of well-known amplification attack protocols (e.g., NTP, CLDAP), which should no longer exist given the established mitigation strategies. Nevertheless, they pose the largest fraction on DDoS amplification attacks within our observation and we witness the emergence of DDoS attacks using recently discovered amplification protocols (e.g., OpenVPN, ARMS, Ubiquity Discovery Protocol). By analyzing the impact of DDoS on core Internet infrastructure, we show that DDoS can overload backbone-capacity and that filtering approaches in prior work omit 97% of the attack traffic.Comment: To appear at PAM 202

Pick-N multiple choice-exams: a comparison of scoring algorithms

To compare different scoring algorithms for Pick-N multiple correct answer multiple-choice (MC) exams regarding test reliability, student performance, total item discrimination and item difficulty. Data from six 3rd year medical students' end of term exams in internal medicine from 2005 to 2008 at Munich University were analysed (1,255 students, 180 Pick-N items in total). Scoring Algorithms: Each question scored a maximum of one point. We compared: (a) Dichotomous scoring (DS): One point if all true and no wrong answers were chosen. (b) Partial credit algorithm 1 (PS(50)): One point for 100% true answers; 0.5 points for 50% or more true answers; zero points for less than 50% true answers. No point deduction for wrong choices. (c) Partial credit algorithm 2 (PS(1/m)): A fraction of one point depending on the total number of true answers was given for each correct answer identified. No point deduction for wrong choices. Application of partial crediting resulted in psychometric results superior to dichotomous scoring (DS). Algorithms examined resulted in similar psychometric data with PS(50) only slightly exceeding PS(1/m) in higher coefficients of reliability. The Pick-N MC format and its scoring using the PS(50) and PS(1/m) algorithms are suited for undergraduate medical examinations. Partial knowledge should be awarded in Pick-N MC exams

Mechanistic studies of electron transfer, complex formation, C-H bond activation, and product binding in soluble methane monooxygenase

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2003.Vita.Includes bibliographical references.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Chapter 1. Soluble Methane Monooxygenase: Activation of Dioxygen and Methane The mechanisms by which soluble methane monooxygenase uses dioxygen to convert methane selectively to methanol have come into sharp focus. Diverse techniques have clarified subtle details about each step in the reaction, from binding and activating dioxygen, to hydroxylation of alkanes and other substrates, to the electron transfer events required to complete the catalytic cycle. Chapter 2. Electron Transfer Reactions of the Reductase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath) Soluble methane monooxygenase (sMMO) catalyzes the hydroxylation of methane by dioxygen to afford methanol and water, the first step of carbon assimilation in methanotrophic bacteria. This enzyme comprises three protein components: a hydroxylase (MMOH) that contains a dinuclear non-heme iron active site, a reductase (MMOR) that facilitates electron transfer from NADH to the diiron site of MMOH, and a coupling protein (MMOB). MMOR uses a non-covalently bound FAD cofactor and a [2Fe-2S] cluster to mediate electron transfer. The gene encoding MMOR was cloned from Methylococcus capsulatus (Bath) and expressed in Escherichia coli in high yield. Purified recombinant MMOR was indistinguishable from the native protein in all aspects examined, including activity, mass, cofactor content, and EPR spectrum of the [2Fe-2S] cluster. Redox potentials for the FAD and [2Fe-2S] cofactors, determined by reductive titrations in the presence of indicator dyes ...(cont.) The midpoint potentials of MMOR are not altered by the addition of MMOH, MMOB, or both MMOH and MMOB. The reaction of MMOR with NADH was investigated by stopped-flow UV-visible spectroscopy, and the kinetic and spectral properties of intermediates are described. The effects of pH on the redox properties of MMOR are described and exploited in pH jump kinetic studies to measure the rate constant of 130 +/- s-1 for electron transfer between the FAD and [2Fe-2S] cofactors in two-electron reduced MMOR. The thermodynamic and kinetic parameters determined significantly extend our understanding of the sMMO system. Chapter 3. Structural Features of the MMOH/MMOR Complex as Revealed by Mass Spectrometric Analysis of Covalently Cross-linked Proteins. Soluble methane monooxygenase requires complexes between its three component proteins for efficient catalytic turnover. The hydroxylase (MMOH) must bind both to the reductase (MMOR) for electron transfer and to the regulatory protein (MMOB) to allow reaction with substrates. Although structures of MMOH, MMOB, and one domain of MMOR have been determined, little is known about structures of the complexes. Proteins cross-linked by a carbodiimide reagent were analyzed by specific proteolysis and capillary HPLC-mass spectrometry. Tandem mass spectra conclusively identified two amine-to-carboxylate cross-linked sites involving the alpha subunit of MMOH and the [2Fe-2S] domain of MMOR (MMOR-Fd). The amino terminus of the MMOH alpha subunit cross-links to the side chains of MMOR-Fd residues Glu56 and Glu91. These Glu residues are close to one another on the surface of MMOR-Fd and far from the [2Fe-2S] cluster ...by Daniel A. Kopp.Ph.D